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What is Aciphex?

Rabeprazole, generic Aciphex, is used to treat the symptoms of gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus. Rabeprazole is used to treat damage from GERD, allow the esophagus to heal, and prevent further damage to the esophagus in adults. Rabeprazole is also used to treat conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome in adults. Rabeprazole is used to treat ulcers (sores in the lining of the stomach or intestine) and is used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers in adults. Rabeprazole is in a class of medications called proton-pump inhibitors. It works by decreasing the amount of acid made in the stomach.

Make sure to always read the patient information and instructions before using this medication. Always follow your doctor’s directions.

• Aciphex is usually taken once a day with a full glass of water.
• This medication is normally used for short-term use and is normally taken for between four and eight weeks although your doctor may recommend a further course of treatment.
• When taking Aciphex for duodenal ulcers, Aciphex should be taken after a meal.
• If taking this medication to prevent ulcers caused by Helicobacter pylori, take it with food.
• If you take this medicine for any other condition, it can be taken either with or without food
• Swallow Aciphex whole without crushing, chewing or breaking it.
• Continue taking rabeprazole for the full prescribed length of time even if your symptoms have improved.
• Tell your doctor if your symptoms do not improve.

• Tell your doctor and pharmacist if you are allergic to rabeprazole, dexlansoprazole (Dexilant), esomeprazole (Nexium), lansoprazole (Prevacid, in Previpac), omeprazole (Prilosec, in Zegerid), pantoprazole (Protonix), any other medications, or any of the ingredients in rabeprazole tablets or sprinkle capsules. Ask your pharmacist for a list of the ingredients.
• Tell your doctor if you are taking rilpivirine (Edurant, in Complera, Odefsey). Your doctor will probably tell you not to take rabeprazole if you are taking this medication. Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antibiotics, anticoagulants ('blood thinners') such as warfarin (Coumadin), atazanavir (Reyataz), cyclosporine (Neoral, Sandimmune), dasatinib (Sprycel), digoxin (Lanoxin), diuretics ('water pills'), erlotinib (Tarceva), itraconazole (Onmel, Sporonox), ketoconazole (Nizoral), iron supplements, methotrexate (Trexall, Xatmep), mycophenolate mofetil (Cellcept), nelfinavir (Viracept), nilotinib (Tasigna), saquinavir (Invirase), and tacrolimus (Prograf). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• Tell your doctor if you have or have ever had a low level of magnesium in your blood, low levels of vitamin B-12 in your body, osteoporosis, an autoimmune disease (condition in which the body attacks its own organs, causing swelling and loss of function) such as systemic lupus erythematosus, or liver disease.
• Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking rabeprazole, call your doctor.

Aciphex (rabeprazole) may cause side effects. Tell your doctor if these symptoms are severe or do not go away:

• headache
• nausea
• vomiting
• constipation
• diarrhea
• gas
• sore throat

Some Aciphex side effects can be serious. If you experience any of the following symptoms, call your doctor immediately, or get emergency medical help:

• blistering or peeling skin
• rash
• hives
• swelling of the eyes, face, mouth, lips, tongue, or throat
• difficulty breathing or swallowing
• irregular, fast, or pounding heartbeat
• excessive tiredness
• dizziness
• lightheadedness
• muscle spasms, cramps, or weakness
• jitteriness
• uncontrollable shaking of a part of the body
• seizures
• severe diarrhea with watery stools, stomach pain, or fever that does not go away
• new worsening joint pain
• rash on cheeks or arms that is sensitive to sunlight
• decreased urination
• blood in the urine

Rabeprazole may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

People who take proton pump inhibitors such as rabeprazole may be more likely to fracture their wrists, hips, or spine than people who do not take one of these medications. People who take proton pump inhibitors may also develop fundic gland polyps (a type of growth on the stomach lining). These risks are highest in people who take high doses of one of these medications or take them for one year or longer. Talk to your doctor about the risk of taking rabeprazole.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.