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What is Cymbalta?

Cymbalta (duloxetine) is a prescription antidepressant used to treat major depressive disorder and generalized anxiety disorder. It belongs to a class of drug called SNRIs (selective serotonin and norepinephrine reuptake inhibitors). Cymbalta may also be used to treat chronic pain caused by diabetes, fibromyalgia, and osteoarthritis.

Always follow your doctor’s instructions and use Cymbalta exactly as prescribed.

• Cymbalta should be taken at the same time each day, with or without food.
• Taking Cymbalta with food can help to prevent nausea.
• Swallow whole. Do not break, chew, or open the Cymbalta capsule.
• It may take up to four weeks before your symptoms improve. Continue taking this medication regularly.

Cymbalta may increase risk of mood changes or suicidal thoughts, especially in patients younger than 24.

Avoid drinking alcohol and operating heavy machinery. Until your body has adjusted to Cymbalta, avoid driving or any activity that requires you to be alert.

Before taking Cymbalta, inform your doctor if you have/are any of the following:

• Seizures
• Liver or kidney disease
• Bleeding or clotting disorders
• History of drug abuse
• Bipolar disorder
• Pregnant or breastfeeding
• Taking NSAIDs (aspirin, ibuprofen, naproxen, celecoxib)

Common side effects of Cymbalta include:

• Dizziness
• Fatigue
• Constipation
• Nausea
• Decreased appetite

More serious side effects include:

• Suicidal thoughts, memory problems, difficulty concentrating
• Liver problems: jaundice, right upper abdominal pain, flu-like symptoms
• Confusion or fainting
• Skin reaction including blisters, hives, rash or sores
• Dark urine or problems with urine flow

How can I make the most out of treatment with Cymbalta?

If you take Cymbalta for depression or anxiety, psychotherapy with a counselor or psychologist can help you better cope with mental health issues.

Is it safe to stop taking Cymbalta?

Like other antidepressant drugs, quitting Cymbalta abruptly can result in withdrawal symptoms. Talk to your doctor about tapering off of Cymbalta, and never stop taking it without your doctor’s guidance.