Fetzima is a prescription medication that is used to treat major depressive disorder. Fetzima contains the selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant drug levomilnacipran and works by affecting the chemicals in the brain that may be unbalanced.

Make sure to always read the patient information and instructions before using this medication. Always follow your doctor’s directions.

• Fetzima can be taken with or without food.
• Take Fetzima at the same time every day.
• Swallow this medication whole without chewing or crushing.
• Do not stop taking this medication suddenly. Refill your prescription in time so there is no pause in treatment.
• You may need your heart rate or blood pressure checked while taking Fetzima.

Tell your doctor and pharmacist:

• About your drug and other allergies.
• If you take any other prescription or over-the-counter medications.
• Your medical history particularly of glaucoma, bipolar disorder, heart problems, stroke, bleeding problems, seizures, high blood pressure, kidney disease, urination problems or low levels of sodium in the blood.
• If you drink alcohol.
• If you have a family history of suicide, depression or manic behavior.
• If you are pregnant or planning pregnancy. Fetzima may cause excessive bleeding after giving birth. DO not start or stop taking this medication without speaking to a doctor.
• If you are breast-feeding. Speak to your doctor if you see signs of feeding problems, trouble gaining weight, agitation, or irritation in the baby.

You should also know:

• Fetzima should not be taken by anyone younger than 18.
• Young people may have suicidal thoughts when first taking antidepressants. Stay alert to mood or behavior changes.
• This medication should not be taken 7 days before or 14 days after taking an MAO inhibitor drug. Speak to your doctor for more information.
• Fetzima may affect your reactions. Do not drive or operate machinery until you can do so safely.
• Avoid drinking alcohol while taking this medication.
• Older adults may be more sensitive to the side effects of this medication.

Common side effects of Fetzima include but are not limited to:

• Irregular heartbeats.
• Decreased sex drive, difficulty achieving an orgasm, or impotence.
• Sweating.
• Nausea or vomiting.
• Constipation.

Get medical help if you have any of the following side effects of levomilnacipran:

• New or worsening symptoms including suicidal thoughts, thoughts about self-harm, panic attacks, sleeping problems, increased depression, anxiety, impulsiveness, hostility, restlessness, hyperactivity, agitation, or aggressiveness.
• Seizures.
• Pounding heartbeats or a fluttering in the chest.
• Eye pain, redness, or swelling or vision changes including blurred vision and tunnel vision.
• Urination is painful or difficult.
• Unusual bleeding, easier bruising, or red or purple spots under the skin.
• Signs of a low sodium level including slurred speech, feeling unsteady, loss of coordination, confusion, headaches, severe weakness, or vomiting.
• Signs of a manic episode including a decreased need for sleep, increased energy, racing thoughts, risk-taking behavior, being talkative, or agitation.
• Signs of serotonin syndrome including fast heart rate, loss of coordination, diarrhea, agitation, hallucinations, nausea, vomiting, shivering, sweating, fever, twitching, or muscle stiffness.
• Symptoms of an allergic reaction such as difficulty breathing, hives, or swelling in your face, lips or throat.

What should I do if I miss a dose of Fetzima?

If you miss a dose of Fetzima, you should take it as soon as you remember. However, if it is almost time for your next dose, then skip your missed dose.

What is the strength of Fetzima?

Fetzima is available in strengths of 20mg, 40mg, 80mg and 120mg.